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KMID : 0370220080520040241
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Yakhak Hoeji
2008 Volume.52 No. 4 p.241 ~ p.251
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Isolation of Flavonoids from Carthami Flos and their Antioxidative Activity
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Chung Sung-Hee
Moon Ye-Ji
Kim Sun-Gun
Kim Kyoung-Young
Lee Kyoung-Tae
Kim Ho-kyoung
Whang Wan-Kyunn
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Abstract
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In this study, isolation of antioxidative compounds was performed for development of anti-oxidizing agent. CHCl3, H2O, 30%, 60% MeOH, MeOH fractions were examined antioxidative activity by DPPH method, TBARS assay, and SOD like activity. It was revealed that 30%, 60% MeOH fractions had significant antioxidative activity. From 30%, 60% MeOH fraction, nine compounds were isolated and elucidated kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (I), quercetin 7-O-β-D-glucopyranoside (II), quercetin 3-O-α-L-rhamnopyranosyl (1→6) β-D-glucopyranoside(rutin) (III), 6-hydroxykaempferol 3-O-β-D-glucopyranoside (IV), kaempferol 3-O-β-D-glucopyranosyl (1→2) β-D-glucopyranoside (V), kaempferol 3-O-β-D-glucopyranoside (VI), luteolin (VII), quercetin 3-O-β-D-glucopyranoside (VIII), apigenin 7-O-β-D-glucuronopyranoside (IX) through physicochemical data and spectroscopic methods (Negative FAB-MS, 1H-NMR, 13C-NMR). Entirely, all compounds had similar antioxidative activity, but more OH group had more antioxidative activity.
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KEYWORD
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Carthami flos, antioxidative effect
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